Ablatus Therapeutics - Norfolk and Norwich University Hospitals NHS FT

Developing a next-generation tumour ablation treatment

Radiofrequency Ablation (RFA) is an established technique for the treatment of solid tumours in situ. RFA uses Alternating Current to generate radiofrequency (RF) energy, which when delivered to target tissues via a probe, results in localised heating and tissue destruction.

However, the heating effect desiccates tissues, increasing their impedance and decreasing their heat conductivity. This leads to charring and the phenomenon of ‘roll-off’ whereby the impendence of the tissue has increased to such an extent that no more RF energy can be deposited and the procedure comes to an end; as such RFA is ultimately self-limiting.

The Technology

Bimodal Electric Tissue Ablation (BETA) was invented by Dr John Cockburn and Dr Simon Wemyss-Holden at the Norfolk and Norwich University Hospital in response to tissue desiccation observed during radiofrequency ablation procedures.

BETA overcomes the limitations of RFA by including a DC element to complement the RF-generating AC. The application of DC to the ablation zone induces electroendosmosis in the target tissue which draws water from surrounding tissues to the ablation probe, thereby preventing tissue desiccation and the increase in impedance that leads to roll-off. The result is substantially greater ablation zones compared to standard RFA and the potential to treat previously untreatable tumours.

By using BETA, an energy-based alternative to open surgery, the device offers a novel, cost-effective and efficient approach to destroying abnormal tissue, such as tumours, in situ and without major surgery. This innovative alternative to existing tissue ablation techniques will potentially allow the ablation of previously untreatable tumours, while improving patient outcomes and providing greater clinical options.

Commercialisation

Ablatus Therapeutics was founded in October 2015, spun out of Norfolk & Norwich University Hospitals NHS Foundation Trust, with support from Health Enterprise East and £125,000 of essential funding granted by the MedTech Accelerator, the joint funding venture led by HEE. Ablatus is also backed by Mercia Asset Management PLC through the Northern VCT Funds.

Ablatus was recently awarded £1.4m by the UK government’s Innovate UK to develop its next-generation, minimally-invasive treatment for soft tissue tumours. The award will fund a 2-year project to develop the prototype device into a final version for use in patients for the first time.

Partnering with Cambridge-based product engineering and design specialists eg technology, and Addenbrooke’s Hospital, the grant will enable Ablatus to push forward with gathering essential clinical data needed for CE mark, commercial launch and ultimately to reach patients.

To find out more please visit the company website : https://ablatus.co.uk/

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